Chaga

Inonotus obliquus

Chaga is a mycological species with a long tradition of use in Siberian medicine, in which it was used to treat intestinal, liver and heart problems. Since the 1960s, studies have been carried out on its effectiveness for oncological processes, cardiovascular and other chronic diseases. This medicinal mushroom stands out for the quantity and variety of naturally occurring polysaccharides it contains. These are immunomodulatory substances of interest in immune system disorders.


Chaga stands out for its quantity and variety of polysaccharides; constituents proven to affect the immune system.

Essential notes about Chaga, the immunoregulatory diamond

Inonotus obliquus, popularly known as Chaga or Tsyr, is a fungus that grows naturally in the northernmost forests of the European continent. Given its immunomodulatory and antioxidant properties, it is known as the “black pearl” or the “forest diamond”.

Chaga has been used for centuries in traditional Siberian medicine, consumed as an infusion made from concentrated powder and water (zavarka), which was recommended to treat intestinal ailments, and liver and heart problems.

In the 1960s, Finnish, American, and Russian scientists conducted various trials that demonstrated its usefulness in cancer processes, cardiovascular and other chronic diseases.

Following these studies, and after the publication of the Cancer Ward by the Russian Nobel Prize winner Aleksandr Solzhenitsyn in 1968, this mushroom gained popularity in the West.

Active Constituents in Chaga

Amongst other bioactive ingredients, the extract of the fruiting body of Chaga contains:

Mycology Notes

  • Chaga (Inonotus obliquus) is a fungus that grows wild in Europe, Russia, Korea, and North America.
  • What we think of as Chaga is not actually the fruiting body (fertile or sexual form) of the fungus I. obliquus, but a sterile conk that grows on the trunks of various living trees.
  • This fungus has a special shape and can be easily identified as a black lump (due to high melanin concentration), which can be reminiscent of a shell or even coal.
  • Its sterile form grows wild on live birch trees, which highlights its black and reddish tones. Medicinal properties have only been found in this sterile conk.
  • Though more research is still needed on the role of Chaga in the ecosystem, there are several articles that indicate it has a contributory role in its environment.

Chaga at the Hifas da Terra Mico-library

At Hifas da Terra, we are running a number of projects aimed at corroborating and certifying the medical qualities of different fungal strains. Our investigations into Inonotus obliquus have allowed us to confirm its usefulness, especially in formulas where a high concentration of immunomodulatory compounds is desirable. In addition, Chaga is considered a relevant source of polyphenols.

Given these qualities and the observed results of its effectiveness, we have incorporated Chaga into the Hifa da Terra Mico-library after the careful selection of strains and the optimisation of its production and extraction process.

Excellent production systems

At Hifas da Terra, one of our main areas of research is the continuous improvement of the cultivation of different mycological species. This is undertaken in specialised bioreactors using certified organic substrates. We ensure the standardisation and quality of raw materials and ingredients which guarantees the excellence of the final product that we create from each mushroom.

Using this innovative system, which we call Mico-Quality®, we identify mycological molecules and ingredients with therapeutic action, carefully select the fungal strains that contain them using our own specific analytical systems, and apply analysis protocols at different manufacturing stages to ensure quality and consistency.

Scientifically proven benefits Chaga

References
  • Balandaykin ME, Zmitrovich IV: Review on Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes): Realm of medicinal applications and approaches on estimating its resource potential. Int J Med Mushrooms, 2015; 17(2): 95–104.
  • Burmasova MA, Utabaeva AA, Sysoeva EV, Sysoeva MA: Melanins of Inonotus obliquus: Bifidogenic and antioxidant properties. Biomolecules, 2019;9(6):248.
  • Досычев ЕА, Быстрова ВН: Лечение псориаза препаратами гриба “Чага”. Вестник Дерматологии и Венерологии, 1973; 5: 79–83.
  • Duru KC, Kovaleva EG, Danilova IG, van der Bijl P: The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies. Phytother Res, 2019;33(8): 1966–1980.
  • Fan LP, Ding SD, Ai LZ, Deng KQ: Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. Carbohydr Polym, 2012;90(2): 870–874.
  • Geng Y, Lu ZM, Huang W, Xu YH, Shi JS, Xu ZH: Bioassay-guided isolation of DDP-4 inhibitory fractions from extracts of submerged cultured of Inonotus obliquus. Molecules, 2013;18(1): 1150–1161.
  • Géry A, Dubreule C, André V, Rioult JP, Bouchart V, Heutte N, Eldin de Pécoulas P, Krivomaz T, Garon D: Chaga (Inonotus obliquus), a future potential medicinal fungus in oncology? A chemical study and a comparison of the cytotoxicity against human lung adenocarcinoma cells (A549) and human bronchial epithelial cells (BEAS-2B). Integr Cancer Ther, 2018;17(3): 832–843.
  • Han ZH, Zhang JC, Liu JN, Dai XD, Kong XH, MA QF, Zhang PQ: Artificial cultivation of Inonotus obliquus. Acta Edulis Fungi, 2010;17(2): 36–42. [in Chinese]
  • Javed S, Mitchell K, Sidsworth D, Sellers SL, Reutens-Hernandez J, Massicotte HB, Egger KN, Lee CH, Payne GW: Inonotus obliquus attenuates histamine-induced microvascular inflammation. PLoS ONE, 2019;14(8): e0220776.
  • Liu P, Xue J, Tong SS, Dong WX, Wu PP: Structure characterization and hypoglycaemic activities of two polysaccharides from Inonotus obliquus. Molecules, 2018;23(8): pii: E1948.
  • Liu ZD, Yu DS, Li L, Liu XX, Zhang HN, Sun WB, Lin CC, Chen JF, Chen Z, Wang WH, Jia W: Three-phase partitioning for the extraction and purification of polysaccharides from the immunomodulatory medicinal mushroom Inonotus obliquus. Molecules, 2019;24(3): pii: E403.
  • Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S: Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res, 2008;28(5A): 2691–2696.
  • Sagayama K, Tanaka N, Fukumoto T, Kashiwada Y: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. J Nat Med, 2019;73(3): 597–601.
  • Staniszewska J, Szymański M, Ignatowicz E: Antitumor and immunomodulatory activity of Inonotus obliquus. Herba Pol, 2017;63(2): 48–58.
  • Sun Y, Yin T, Chen XH, Zhang G, Curtis RB, Lu ZH, Jiang JH: In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae). Int J Med Mushrooms, 2011;13(2): 121–130.
  • Xue J, Tong SS, Wang ZR, Liu P: Chemical characterization and hypoglycaemic activities in vitro of two polysaccharides from Inonotus obliquus by submerged culture. Molecules, 2018;23(12): pii: E3261.
  • Yong TQ, Chen SD, Liang DL, Zuo D, Diao X, Deng CL, Wu YN, Hu HP, Xie YZ, Chen DL: Actions of Inonotus obliquus against hyperuricemia through XOD and bioactives screened by molecular modelling. Int J Mol Sci, 2018;19(10): pii: E3222.
  • Zhang LX, Fan C, Liu SC, Zang ZF, Jiao LL, Zhang LP: Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus. J Med Plant Res, 2011;5(7): 1251–1260.
  • Zheng WF, Liu T, Xiang XY, Gu Q: Sterol composition in field-grown and cultured mycelia of Inonotus obliquus. Acta Pharmacol Sin, 2007;42(7): 750–756.
  • Zheng WF, Zhao YX, Zhang MM, Yin ZJ, Chen CF, Wei ZW: Phenolic compounds from Inonotus obliquus and their immune-stimulating effects. Mycosystema, 2008;27(4): 574-581.
  • Isokauppila T: Healing Mushrooms : A Practical and Culinary Guide to Using Mushrooms for Whole Body Health. New York : Avery, 2017. 215 p. ISBN 978-0-7352-1602-0
  • Lelley J: Die Heilkraft der Pilze : Gesund durch Mykotherapie. Düsseldorf : München : ECON Verlag GmbH, 1997. 236 p. ISBN 3-430-15953-9
  • Powell M: Medicinal Mushrooms : A Clinical Guide. 2nd updated and expanded ed. Mycology Press, 2014. 152 p. ISBN 978-0-9566898-2-5
  • Rogers R: The Fungal Pharmacy : The Complete Guide to Medicinal Mushrooms & Lichens of North America. Berkeley, CA : North Atlantic Books, 2011. 591 p. ISBN 978-1-55643-953-7

This website uses cookies so that you can have the best user experience. If you continue browsing you are giving your consent for the acceptance of the mentioned cookies and the acceptance of our cookies policy, Click on the link for more information.plugin cookies

ACEPTAR
Aviso de cookies