In Hifas da Terra we use biotechnology, innovation and ecology to develop formulas that help health care from the bioactive substances of mushrooms and medicinal mushrooms that we research, produce, extract and purify.

We put scientific knowledge in Mycology applied to the service of people’s well-being, developing research studies and clinical trials that allow us to validate results of safety and efficacy based on evidence without forgetting our social responsibility and commitment to the environment.

Research areas and R&D projects

Human health

Nutrition and coadyuvance in oncological, autoimmune, cardiovascular and neurodegenerative pathologies.

Animal health

Nutrition and supplementation to reduce the use of antibiotics and improve parameters of well-being and quality of life.

Environment

Phytopathology study and rehabilitation of soils affected by hydrocarbons, heavy metals, fires and mining industries.

Research collaborators

Galician Biomedicine Foundation

Spanish University Hospital
R&D project Micromarker

University of Vigo
R&D Project CosmetInnova

Inibic

Inibic
R&D Project FungiTechOnco

Santiago de Compostela Hospital

Santiago de Compostela Hospital
R&D Project Dismetasín

Human Health

Nutrition and coadyuvance in oncological, autoimmune, cardiovascular and neurodegenerative pathologies.

Oncology

Microinmunomama

2020-2023

Development of a new nutritional supplement which modulates the immune response and intestinal microbiota, and a study of the benefits of this supplement in breast cancer.

The main goal of the project is the development of a new product capable of modulating the intestinal microbiota and immune function in breast cancer patients using an innovative mushroom culture and extraction process.

The product will be functionally validated in vitro and in vivo, in natural animal models of cancer (Centro Rof. Codina), and finally in a human trial. Study data will include classical biomarkers, omics, histological techniques, and the assessment of nociception to:

  1. Allow a better understanding of the mechanisms and processes involving the intestinal microbiota in breast cancer.
  2. Study whether the modulation of the microbiota promotes an improvement in the treatment of cancer and can prevent side effects of current treatments such as chemotherapy-associated neuropathy.

Clinical trial

The final part of the project will evaluate the efficacy and benefits of the new product on breast cancer patients’ health. In this study, the gut microbiota will be monitored using molecular multi-omic platforms.

Funding: the Microimmunomama project is funded by the Retos program.

Participating organisations: the project was initiated by Hifas da Terra in collaboration with the Leitat technology center, and the Fundación Biomédica Galicia Sur, which work out of hospitals in Vigo, Pontevedra, and Ourense.

Neurodegenerative diseases

Neurofood

2018-2020

The Galician companies Hifas da Terra, Cuevas and Cía and Algamar have started the Neurofood project. This is an R&D initiative to develop functional foods and food supplements from Galician foods of high nutritional value such as medicinal mushrooms, chestnuts and algae.

These have already confirmed the presence of certain triterpenoid compounds, vitamins, minerals and other essential nutrients that could affect aspects related to neurocognitive development and, specifically, with perception, memory, attention and learning.

Neurofood is a “comprehensive project” because it provides, after the research phases, the development of specific products and their functional validation in healthy individuals and patients, both early and advanced.

Project funded by the Galician Innovation Agency and developed with the support of the Ministry of Economy, Economy and Industry of the Xunta de Galicia.

  • Budget: Hifas da Terra S.L. (310 303,29 €); Cuevas y Cía S.A. and Algamar.
  • Approved subsidy: Hifas da Terra S.L. (186 181,97 €); Cuevas y Cía S.A. and Algamar.
  • Collaborative project: Hifas da Terra, Cuevas y Cía, Algamar, Foltra Foundation, Anfaco-Cecopesca, Centro Tecnolóxico da Carne and University of Santiago de Compostela (USC).

Oncology

Micromarker

2018-2021

Collaborative R & D project led by Hifas da Terra in which the relationship between the modulation of the intestinal microbiota and the progression of colorectal cancer will be evaluated, as well as the repercussions that the use of prebiotic and anti-inflammatory compounds derived from the fungi in the quality of life of cancer patients. This initiative has the support of the CDTI, the financing mediator of the general administration of the state of the business R + D + i.

  • Budget: 686 € 409

Oncology

CRC-Folfox

2018-2019

Pilot study for the evaluation of the benefits of formulas with medicinal mushrooms in patients with colorectal cancer who present peripheral neuropathies derived from the chemotherapy treatment.

Oncology

FungiTechOnco

2015-2017

Project for the industrial development of the cultivation of medicinal mushroom species to obtain new compounds with anticancer activity applicable in products aimed at the prevention and treatment of gastric and colorectal cancer.

  • Overall budget of the project: 1 245,438 €
  • Hifas da Terra global budget: 501 533 €
  • Subsidy approved to Hifas da Terra: 300 919,80 €
  • Collaborative project (call FEDER-INNTERCONECTA): Hifas da Terra, CZ Veterinary and Research Group in Clinical and Translational Oncology of the Biomedical Research Institute of A Coruña (INIBIC).

Cardiovascular health

Dismetasín

2015-2017

Project for the selection of ingredients with healthy properties in the industrial development of target foods to reduce the incidence of metabolic syndrome (MS).

  • Overall budget of the project: € 1 682 326
  • HdT budget for the project: € 298,000
  • Total subsidized amount to Hifas da Terra: 178 800 €
  • Collaborative project (FEDER-INNTERCONECTA call): Hifas da Terra, Aceites Abril, Alibós, Anfaco-Cecopesca, Clesa, Friobas Basilio, Ramón Domínguez Foundation – Network Biomedical Research Center of the Physiopathology of Obesity and Nutrition (CIBEROBN), Complex University Hospital of Santiago de Compostela (CHUS) and University of Murcia.

Osteoarticular Health

Mico Artro

2018

Pilot evaluation of the efficacy, safety and tolerability of a daily oral dose of an experimental Mycotherapy protocol in patients with osteoarthritis of the knee for three months.

Self-funded collaborative project: Hifas da Terra and the Osteoarthritis Foundation International (OAFI).

Animal health

Nutrition and supplementation to reduce the use of antibiotics and improve parameters of well-being and quality of life.

Mico Swine

Research project to improve animal health and welfare, production parameters and meat quality in pig farms.

Mico Apis

Research project to improve the health and welfare of the hive, productive parameters and quality of honey in apiaries

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HdT Scientific publications

International Journal of Medical Sciences

2019

In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes versicolor and Grifola frondosa in Colon Cancer Cells.

Developmental Perinatal and Paediatric Pharmacology Congress

2017

Clinical utility and safety of Ganoderma lucidum (Bio-Ganoderma) in Acute Lymphoblastic Leukaemia as a adjuvant therapy: a case report (Póster N.º 30).

III Conference on Biomedical Cancer Research in Galicia

2016

Study of the toxicity produced by the treatment with extracts of edible fungi in colon carcinoma.

LWT – Food Science and Technology

2015

Sequential extraction of Hericium erinaceus using green solvents.

Hindawi Publishing Corporation

2014

Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Cordyceps sinensis.